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From left
to right: Suba Iyer, Dongyang
Yu, Liane Agulto, Alyson Yoder,
Jeremy Kelly, Zhongwei Tang,
Li Dong and Yuntao Wu.
We are very excited
to be able to support the remarkable
research coming out of Dr. Wu's
Manassas, VA lab at George Mason
University. We're also thrilled
that his dedicated team has
volunteered to take a few days
away from the lab to both ride
and provide crew support to
our riders!
Dr. Wu, who is
only 40, has spent the past
six years decoding the process
by which the HIV virus attacks
T cells. This is the very "return
to basic science" that
was recently called for by Dr.
Robert Gallo, the co-discoverer
of the HIV virus. Dr. Wu believes
that the next level of therapies
will not come in the form of
a vaccine or cure, to totally
eliminate the virus from the
body. Rather, he is focused
on keeping the virus from multiplying
within a host body.
By raising $200,000
for the next stage of research,
we will enable this promising
young scientist and his team
to accelerate his research and
bring us closer to defeating
HIV and AIDS.
Read what the
Fairfax Times wrote
about Dr. Wu in its June 25th
edition:
Virologist
Dr. Yuntao Wu of George Mason
University may be able to stop
HIV, he just needs the funding.
The cocktail of toxic drugs
prescribed for HIV patients
halts viral replication, keeping
the virus at bay. But it only
takes weeks for a viral rebound
after therapy is discontinued.
The goal is to get people
off the drugs and kill the virus.
HIV resurfaces because
of a reservoir of fortified
human cells, allowing the virus
to remain in an infectious state,
immune to anti-retroviral drugs.
Wu's “Trojan horse” concept
cleans out infected HIV microphages,
or white blood cells, replacing
the HIV with anthrax.
Because WU's artificial
particle looks like HIV, it
has to rely on HIV protein,
selectively killing off neighboring
infected cells.
So far, in a test tube,
the study has yielded positive
results. The next phase of research
will have to involve animal
testing, with costs running
into hundreds of thousands of
dollars.
“The test works very well,
not 100-percent effective yet,
but it can kill a large number
of infected cells," Wu
said. "The problem is that
(human) bodies are very complicated,
but test tubes are easy."
There is “a lot of pressure,
especially in our field. Funding
is very tight,” Wu said, because
“90 percent of HIV/AIDS research
projects applying for grants
can't get funding.”
Wu said his research stands
alone in the world. Having developed
the concept since 2001, he said
initial lab work to final FDA
approval to mass distribution
takes a minimum of 10 years.
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